PART 1: FOUNDATIONS OF PATHOPHYSIOLOGY
1. Introduction to the Basics of Pathophysiology
2. Genetics, Genomics, and Epigenomics
3. Environmental Influences on Disease and Injury
4. Stress and Adaptation
PART 2: RISKS UNDERLYING THE LEADING CAUSES OF MORBIDITY AND MORTALITY
5. Health Risks of Obesity and Physical Inactivity
6. Risks Related to Substance Use Disorders
7. Risks Related to Sleep Alterations
PART 3: FLUID, ELECTROLYTE, AND ACID-BASE IMBALANCES
8. Fluid and Electrolyte Imbalances
9. Acid-Base Imbalances
PART 4: CELL INJURY, INFLAMMATION, AND ALTERATIONS OF CELL GROWTH AND REGULATION
10. Mechanisms of Cell Injury and Aging
11. Inflammation
12. Neoplasia
PART 5: INFECTION AND DISORDERS OF IMMUNITY
13. Mechanisms of Infection and Host Protection
14. Hypersensitivity and Autoimmune Disorders
15. Immunodeficiency Disorders
16. Disorders of White Blood Cells
PART 6: DISORDERS OF OXYGENATION
17. Restrictive Lung Disorders
18. Obstructive Lung Disorders
19. Neoplastic, Infectious, and Pulmonary Vascular Lung Disorders
20. Respiratory Failure
21. Disorders of Oxygen Transport
PART 7: DISORDERS OF PERFUSION
22. Alterations of Hemostasis
23. Vascular Disorders
24. Coronary Circulation Disorders
25. Cardiac Structural Disorders
26. Heart Failure
27. Disorders of Circulation within the Central Nervous System
28. Shock and Multiple Organ Dysfunction Syndrome
PART 8: DISORDERS OF MOOD AND COGNITION
29. Disorders of Emotional Regulation
30. Disorders of Neurodevelopment and Neurocognition
PART 9: DISORDERS OF SENSORY PERCEPTION AND THERMOREGULATION
31. Disorders of Hearing, Balance, and Vision
32. Pain, Neuropathy, and Headache
33. Disorders of Thermoregulation
PART 10: DISORDERS OF MOBILITY
34. Disorders Affecting Motor Function
35. Acute Musculoskeletal Disorders
36. Chronic Musculoskeletal Disorders
PART 11: DISORDERS OF ENDOCRINE REGULATION
37. Diabetes Mellitus
38. Thyroid, Parathyroid, and Adrenal Disorders
PART 12: ALTERED TISSUE INTEGRITY
39. Tissue and Wound Healing
40. Acute Skin Disorders
41. Chronic Skin Disorders
PART 13: DISORDERS OF DIGESTION, METABOLISM, AND ELIMINATION
42. Disorders of the Upper and Lower Gastrointestinal System
43. Disorders of the Exocrine Pancreatic and Hepatobiliary Systems
44. Liver Failure
45. Disorders of Kidney and Urinary Tract Structure and Function
46. Acute Kidney Injury and Chronic Kidney Disease
PART 14: DISORDERS OF SEXUALITY AND REPRODUCTION
47. Disorders of the Female Reproductive System
48. Disorders of the Male Reproductive System
49. Sexually Transmitted Infections
PART 15: TRAUMA AND MULTISYSTEM CONDITIONS
50. Mechanisms of Traumatic Injury
51. The Pathophysiology of Primary and Secondary Traumatic Injury
52. Biologic, Chemical, and Radiologic Agents of Disease
53. Pathophysiology at the End of Life